Praha City Center takes the space between Klimentska and Petrska streets in Prague´s prime first district, close to the Namesti Republiky. The entrance to the building is either from Petrska or Samcova streets.

The building is situated right in the central business district of Prague, state and local authorities; several hotels and numerous shops and restaurants are located in the surrounding area. Its location guarantees excellent traffic access by public transport and by car from the city highway. Metro lines B (stations Florenc or Namesti Republiky) and C (station Florenc) and a tram stop Bila labut (tram no. 3, 8, 24 and 26) are within a short distance. Prague´s main bus terminal (Florenc) and train station Prague - Center (Masarykovo nadrazi) are also within walking distance.